Influence of dosing time interval and dose by cohort. (A-B) Study 103. LDH over time by patient. Dotted lines delineate the following LDH categories: normal, 53 to <234; 1× to 1.5× ULN, 234 to 351; >1.5× to 2× ULN, 352 to 468; >2× ULN, > 469. (C) Study 201. Mean (95% confidence interval) LDH over time. Doses shown for each cohort are maintenance doses. Green arrows represent the primary efficacy end point.