Microenvironmental immune cell signatures dictate clinical outcomes. (A) Kaplan-Meier curves for PTCL-NOS patients with or without B-cell (left) and DC (right) signatures. P values were calculated using a log-rank test. (B) Kaplan-Meier curves for 63 PTCL-NOS patients in an independent cohort⁴  were generated based on indicated gene signatures. P values were calculated using a log-rank test. (C) PTCL-NOS cases were stratified into 4 subgroups according to B-cell and DC signatures, and Kaplan-Meier curves were generated. P values were calculated using a log-rank test. (D) Clinical courses of 33 cases. Bar graphs represent survival duration for each patient. Responses to initial therapies are indicated at left. Time of disease progression is depicted as a gray circle. Cases lacking B-cell and DC signatures (non-BD subgroup) were generally resistant to initial therapy (left). B only, only B-cell-signature–positive cases; BD, B-cell– and DC signature–positive cases; CR, complete remission; D only, only DC signature–positive cases; non-BD, cases without B-cell and DC signatures; PD, disease progression; PR, partial remission.