Effect of SC411 on selected biomarkers of adhesion, coagulation, and hemolysis. After 8 weeks of treatment, statistically significant reductions were observed in soluble E-selectin (A) (P = .0219), and D-dimer (B) (P = .025) in patients exposed to the 36 mg DHA/kg dose of SC411 vs placebo. Hemoglobin was significantly increased compared with baseline at doses 20 and 36 mg/kg and against placebo at 20 mg DHA/kg vs placebo (C) (P < .001). No significant difference was observed lactate dehydrogenase (D). *Significance vs placebo.