Figure 4.
![Figure 4. IV-injected Co-HP inhibited rhodocytin-induced platelet aggregation. Five minutes (A) or 48 hours (B) after IV injection of 1% DMSO or Co-HP (estimated final concentration of 10 μg/mL [15 μM]), the mice were euthanized and the blood was drawn from the IVC with 5% final concentration of ACD. PRP was stimulated by the indicated concentrations of rhodocytin, collagen, or PAR4-AP (thrombin receptor activator peptide) and platelet aggregation was monitored for 10 minutes using a platelet aggregometer.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/2/17/10.1182_bloodadvances.2018016261/3/advances016261f4.jpeg?Expires=1735513392&Signature=MAV2IIkx1HMWm3KjE1Krm2qx3bWmBQGxxMFfoh-KN8mDlh-0Vf8kRvaLiUPEFRhMl-4XbbLd~8UI~UqG9F~jJlkTOtxVuUd77xZlNKLLkXTNTajX3Hp1gb7PSz-psLpWMoIUbCsxR4yO-KF023jjFwVhvRCgdO1o0ZI106Pgwd~iqIKnBzh~PnhyhX0gOQBk3nVrIWUm52L9A4i0RFgw-Dv0EkAYT21PEHKg1lwAp6K5q7SBiA8P-8PIWM6gwbLt-uoyxmqHx85HRjf1XrVu15BXINYmPV5bd8nNsNZJgZL-D6B0iC80aJCBzgHfcFupE518TGOGxUkIjcyFJexS3A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
IV-injected Co-HP inhibited rhodocytin-induced platelet aggregation. Five minutes (A) or 48 hours (B) after IV injection of 1% DMSO or Co-HP (estimated final concentration of 10 μg/mL [15 μM]), the mice were euthanized and the blood was drawn from the IVC with 5% final concentration of ACD. PRP was stimulated by the indicated concentrations of rhodocytin, collagen, or PAR4-AP (thrombin receptor activator peptide) and platelet aggregation was monitored for 10 minutes using a platelet aggregometer.
