(A) Progression-free survival in 220 patients with CLL according to ZAP-70 expression as detected by flow cytometry. ZAP-70 negative (< 20% of leukemic cells): 140 patients; ZAP-70 positive (> 20% of leukemic cells): 80 patients (Barcelona series; updated). (B) Overall survival in 220 patients with CLL according to ZAP-70 expression as detected by flow cytometry. ZAP-70 negative (< 20% of leukemic cells): 140 patients; ZAP-70 positive (> 20% of leukemic cells): 80 patients (Barcelona series; updated).