Figure 1.
![Figure 1. Supra large VWF multimers in 3 siblings (thrombotic thrombocytopenic purpura [TTP]) with hereditary ADAMTS13 deficiency compared to normal plasma (NP). Activation of ADAMTS13 in normal plasma (NP +a) results in complete proteolytic cleavage of VWF multimers, whereas VWF in the TTP patient (TTP +a) remains unchanged due to the lack of ADAMTS13.](https://ash.silverchair-cdn.com/ash/content_public/journal/hematology/2006/1/10.1182_asheducation-2006.1.86/5/schneppenheim_fig1.jpeg?Expires=1735500885&Signature=jrHfwZIqnKLI2KNFkzI4KRVFzhStR7-odAIyEVoDPN2zVejHoPLkAPAS7MOpO8wnypRaoUokLAiwogKR6ta4-l10iiXFfOc3eLKK3~qo3ujemsGJlSM3wK3kGZlkMnE~tWttBEBrGLa1GO515iIxos6X3udJBjq2-~5LyH2br5ppKdbpuyNNckNrIzsXO0erd0lcrjXMeSYBano71Y8mOXH-opwFG78TCAHPMFvF5n9SjQhctXfxJDZRqrCk~~5Dky8xeYJYJoyhb2VbDVLMYVfnaV2B76m1k0wTAu3HaWMRxKhOfuT0lvF8IFtR3FD8hUFWgU8qFc6pPPU6cVX--w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Supra large VWF multimers in 3 siblings (thrombotic thrombocytopenic purpura [TTP]) with hereditary ADAMTS13 deficiency compared to normal plasma (NP). Activation of ADAMTS13 in normal plasma (NP +a) results in complete proteolytic cleavage of VWF multimers, whereas VWF in the TTP patient (TTP +a) remains unchanged due to the lack of ADAMTS13.
