Downing Figure 4.
Downing Figure 4. Schematic representation of PAX5 deletions in pediatric acute lymphoblastic leukemia (ALL). / (A) PAX5 domain structure. PD, paired domain; O, octomer; H, homeodomain-like; TAD, transactivation domain. (B) PAX5 genomic organization and extent of PAX5 hemizygous deletions (solid line), homozygous deletions (dashed line), and amplification (red line). (C–D) Fluorescent in situ hybridization of interphase nuclei showing mono-allelic deletion (C) and focal internal amplification of PAX5 (D) within leukemic blasts. PAX5 probe is green, control probe red.

Schematic representation ofPAX5deletions in pediatric acute lymphoblastic leukemia (ALL).

(A) PAX5 domain structure. PD, paired domain; O, octomer; H, homeodomain-like; TAD, transactivation domain. (B) PAX5 genomic organization and extent of PAX5 hemizygous deletions (solid line), homozygous deletions (dashed line), and amplification (red line). (C–D) Fluorescent in situ hybridization of interphase nuclei showing mono-allelic deletion (C) and focal internal amplification of PAX5 (D) within leukemic blasts. PAX5 probe is green, control probe red.

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