American Society of Hematology

Chiorazzi Figure 1.

$Chiorazzi Figure 1. Examples of kinetics of B-cell chronic lymphocytic leukemia (B-CLL) cell birth (B) and death (D). / Percent 2H enrichment in the DNA of leukemic cells was measured and converted into a fraction of labeled cells (⋄, left vertical axis) as described.27 A two-compartment model was fit to the data using non-linear curve fitting software. WBC counts taken during the study are plotted on a log scale at right vertical axis (X). An exponential growth function was fit to the WBC data to provide a growth rate for the leukemic cells in the blood (Table 2). / A. Three patients with faster birth rates. / B. Three patients with slower birth rates. / Calculated death rates vary and correlate with changes in WBC levels.$

Examples of kinetics of B-cell chronic lymphocytic leukemia (B-CLL) cell birth (B) and death (D).

Percent ²H enrichment in the DNA of leukemic cells was measured and converted into a fraction of labeled cells (⋄, left vertical axis) as described.²⁷ A two-compartment model was fit to the data using non-linear curve fitting software. WBC counts taken during the study are plotted on a log scale at right vertical axis (X). An exponential growth function was fit to the WBC data to provide a growth rate for the leukemic cells in the blood (Table 2).

A. Three patients with faster birth rates.

B. Three patients with slower birth rates.

Calculated death rates vary and correlate with changes in WBC levels.

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