IL-13 dependent ILC2 induced expansion of donor MDSCs. (a) Frequencies CD11b+/GR-1+/Ly-6C+/Ly-6G+ MDSCs in the LP of the colon of allo-SCT recipients 12 days post-transplant with or without WT ILC2s. These represent 2 independent experiments, bar graphs are average ± SEM, student's t test using GraphPad Prism, * p<0.05. (b) Frequency of MDSCs in the LP of the colon of allo-SCT recipients with or without IL-13-/- ILC2s. These represent 2 independent experiments, bar graphs are average ± SEM. (c) B6D2 recipients of B6 T cell depleted bone marrow (BM only), BM plus splenic T cells (BM + T cells) or BM plus T cells with cultured IL-13-/- ILC2 (BM, T cell + IL-13-/- ILC2) were evaluated for percent survival following allo-SCT, one representative of 2 combined experiments shown (n=8 per group in each experiment) p=0.1, by Log-rank (Mantel-cox) test.

IL-13 dependent ILC2 induced expansion of donor MDSCs. (a) Frequencies CD11b+/GR-1+/Ly-6C+/Ly-6G+ MDSCs in the LP of the colon of allo-SCT recipients 12 days post-transplant with or without WT ILC2s. These represent 2 independent experiments, bar graphs are average ± SEM, student's t test using GraphPad Prism, * p<0.05. (b) Frequency of MDSCs in the LP of the colon of allo-SCT recipients with or without IL-13-/- ILC2s. These represent 2 independent experiments, bar graphs are average ± SEM. (c) B6D2 recipients of B6 T cell depleted bone marrow (BM only), BM plus splenic T cells (BM + T cells) or BM plus T cells with cultured IL-13-/- ILC2 (BM, T cell + IL-13-/- ILC2) were evaluated for percent survival following allo-SCT, one representative of 2 combined experiments shown (n=8 per group in each experiment) p=0.1, by Log-rank (Mantel-cox) test.

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