Impact of miRNA signature on transcriptional factors and cancer related function. A) For young males it was determined that the key miRNA signature has impact on oncogenes, MYC and JUN, along with other mRNAs determined using CluePedia Cytoscape plugin. The miRNA-mRNA interactions were determined from three different databases as indicated by the figure legend. B) Using Ingenuity Pathway Analysis (IPA) the functional impact of the miRNA signature is shown for young males comparing Smurf2-/- mice to wild-type (WT) mice.