Figure 1.
Figure 1. T stem cell memory dynamics during acute GVHD. / A-B) The frequencies (A) and absolute numbers (B) of CD8 T stem cell memory cells identified as CD3+CD14/20-CD8+CD45RA+CCR7+CD95+ lymphocytes and tracked longitudinally by flow cytometry following allogeneic HCT in primary (red circles) and breakthrough (black open circles) GVHD. Data display mean ± SEM. *p<0.05 using multiple t-test with Sidak-Bonferroni correction. / C) The ratio between Tscm and more differentiated memory/effector T cell subsets (Teff: summary of central memory (CD45RA-CCR7+), effector memory (CD45RA-CCR7-) and terminally differentiated effector (CD45RA+CCR7-) CD8+ T cells at 2 different time points: (1) At the time of maximal expansion of Tscm cells prior to the clinical development of breakthrough GVHD (T1) and (2) When recipients developed clinically significant breakthrough GVHD (T2). *p<0.05 using paired t-test.

T stem cell memory dynamics during acute GVHD.

A-B) The frequencies (A) and absolute numbers (B) of CD8 T stem cell memory cells identified as CD3+CD14/20-CD8+CD45RA+CCR7+CD95+ lymphocytes and tracked longitudinally by flow cytometry following allogeneic HCT in primary (red circles) and breakthrough (black open circles) GVHD. Data display mean ± SEM. *p<0.05 using multiple t-test with Sidak-Bonferroni correction.

C) The ratio between Tscm and more differentiated memory/effector T cell subsets (Teff: summary of central memory (CD45RA-CCR7+), effector memory (CD45RA-CCR7-) and terminally differentiated effector (CD45RA+CCR7-) CD8+ T cells at 2 different time points: (1) At the time of maximal expansion of Tscm cells prior to the clinical development of breakthrough GVHD (T1) and (2) When recipients developed clinically significant breakthrough GVHD (T2). *p<0.05 using paired t-test.

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