Overall survival in patients stratified according to HLC ratio values. a) Median survival was 31.7 months in patients with abnormal HLC ratio values (dotted line) and was not reached in patients with normal values (full line, p = 0.021). b) the difference is even bigger when patients were stratified by extreme values of HLC ratio (< 0.02 or > 40). Median survival was 11.8 months in patients with extreme HLC ratio values (dotted line) and 31.7 months in patients with less extreme values (full line, p = 0.0032).