Time to progression in patients stratified according to HLC ratio values. a) Median time to progression was 21.1 months in patients with abnormal HLC ratio values (dotted line) and was not reached in patients with normal values (full line, p = 0.006). b) when patients were stratified by extreme values of HLC ratio (< 0.02 or > 40), median time to progression was 11.8 months in patients with extreme HLC ratio values (dotted line) and 23.1 months in patients with less extreme values (full line, p = 0.0004).