Figure 1.
![Figure 1. Stem cell-based in vitro models and biomarkers for studying the hematotoxic effects of fluoranthene exposure. (A) Direct exposure of PAHs depressed the proliferative capacity of h-TERT cells with a thread-like or round shape and loose cell-to-cell attachment. (B) Cytotoxic effect of fluoranthene exposure to the bone marrow-mesenchymal stem cells remarkably increased with dose-dependent manner. (C) Identified potential biomarkers were categorized as their biological processes and molecular functions. (D) Immunoblot confirmed the increased expression of poly [ADP-ribose] polymerase 1 (PARP-1) after exposure of fluoranthene.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/124/21/10.1182_blood.v124.21.5976.5976/5/67796fig01.jpeg?Expires=1748001827&Signature=pjTEqxWHwCFTSnok-Bc3y1GuGSE-B7waWVqedjjTckJdl2DINDwKRyxIbd2J3AHpfBBgFPUjROQAc0K2YtmtBmPZ8T8ILRH9nY9hzaPbTOrLzbMsXFcgxyeGgTRix7wWYmgJv8W0~DJUGldb5phskm5ttWHv1vfhGJv5xsD8B9tm~TWB5uNjsvhQyeQit17QsRZAjA~6A9AIyZK7-BBHmzm9lIpIGoS4LUuq61uMy8NO8I71~p-ibd3FmvBNCFcscnJaAy~FuAlyAQLrd4d1X2LYXV73mHRtPXXjPygPcefryXbTijrCh9YxN4zwdlWszJzVQcKTq5-weOrRRt80JA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Stem cell-based in vitro models and biomarkers for studying the hematotoxic effects of fluoranthene exposure. (A) Direct exposure of PAHs depressed the proliferative capacity of h-TERT cells with a thread-like or round shape and loose cell-to-cell attachment. (B) Cytotoxic effect of fluoranthene exposure to the bone marrow-mesenchymal stem cells remarkably increased with dose-dependent manner. (C) Identified potential biomarkers were categorized as their biological processes and molecular functions. (D) Immunoblot confirmed the increased expression of poly [ADP-ribose] polymerase 1 (PARP-1) after exposure of fluoranthene.
