P53 expression and cell apoptosis were simultaneously detected on bone marrow cytospins from del(5q) patients respectively by APAAP and apoptosis. P53 positive cells (red signal indicted by black arrows in panel A and C) did not present apoptosis signal (white arrow in panel B and D), While Apoptosis cell (red arrow in panel B and D) showed p53-negeative signal (yellow arrow in panel A and C).