Presence of three mutations in α spectrin within the B. family, leading to Hereditary Elliptocytosis (HE) and Hereditary Pyropoikilocytosis (HPP). It concerns the HE mutations in Exon 2 (59 G/A) and Exon 6 (103 T/C). In addition, the LELY (Low Expression Lyon) mutation is present, which leads to reduced expression/synthesis of α spectrin.