In contrast to IM, dasatinib intracellular uptake and retention (IUR) is not significantly different in CML-CD34⁺and mature CD34^-cells: (A) OCT-1 activity and IM IUR is significantly lower in CML-CD34⁺ than CD34^- cells (p=0.04). (B) However, dasatinib IUR is not significantly different in CD34⁺ and CD34^- cells (p=0.8) (C) OCT-1 mRNA expression is lower in CML-CD34⁺ cells than CD34^- cells. While ABCB1 expression is significantly higher in CML-CD34⁺ compared to CD34^- cells (p=0.007).