Comparative analysis of the MLL-AF4 target genes reported by Guenther et al19 in MLL-AF4 and MLL-AF4/FLT3-TKD hESC-derived CD45+ hematopoietic cells. (A) Heatmap diagram depicting the expression of the MLL-AF4 target genes reported by Guenther et al19 for EV-, MLL-AF4-, and MLL-AF4/FLT3-TKD hESC-CD45+ blood cells. The upper color bar codifies the gene expression in a log2 scale. Expression levels vary from highly expressed (red) to nonexpressed (green) genes. (B) Number of MLL-AF4 target genes (of the159 reported by Guenther et al19 ) found differentially expressed in MLL-AF4 vs EV hESC-CD45+ cells and MLL-AF4/FLT3-TKD vs MLL-AF4 hESC-CD45+. (C) The MLL-AF4 target genes reported by Guenther et al19 differentially expressed in MLL-AF4 vs EV hESC-CD45+ cells (left panel) and MLL-AF4/FLT3-TKD vs MLL-AF4 hESC-CD45+ (right panel) were classified by IPA software. The z score is an estimation of the activation/inhibition status of a given category within an altered gene function. (D) List of MLL-AF4 target genes differentially expressed between MLL-AF4/FLT3-TKD and MLL-AF4 hESC-CD45+ cells.
