KL dose-response in β thalassemic patients. Cell growth (top panels) and HbF content (bottom panels) in minibulk HPC unilineage erythroid cultures derived from a representative β-TI (left panels) and β-TM patient (right panels), supplemented or not with graded amounts of KL (1, 10, or 100 ng/mL). The total cell number is shown in top panels. The percentage of HbF content (evaluated as the γ/[β + γ] and γ/α ratio in β-TI and β-TM, respectively) is reported in bottom panels.