Promoter activity of different CPB2 5′-flanking region haplotypes. Substitutions were introduced into the wild-type (wt; H1 haplotype) sequence31 in the context of the TAFI[−2699]-luc luciferase reporter plasmid in the haplotypic combinations shown in Figure 1. Transfections and reporter gene assays were performed as described in the legend to Figure 2. The data shown are the means plus or minus SEM of 4 independent experiments.