The progressive changes of hematologic parameters (hemoglobin [Hb], white blood cell count [WBC], and platelet count [PLT]; on the left y-axis) and of JAK2V617F allele burden (percent value; on the right y-axis) in samples collected at different times after AML diagnosis. Clinically relevant events (diagnosis of AML or PV, autologous hematopoietic stem-cell transplantation [HSCT], and onset of pruritus) are marked by arrows on the top of the figure.