Lymphoproliferative disease in Stat6VT transgenic mice (A) Photograph of mouse with lymphoproliferative disease. Spleen is extended through entire peritoneum (). Lymphadenopathy is also apparent. (B) Comparison of spleen size from wild-type mouse (bottom left) compared with spleen from mouse with LPD. (C) Flow cytometric analysis of splenocytes from wild type, Stat6VT transgenic and 2 Stat6VT transgenic mice with LPD. Numbers in quadrants represent percentage of total spleen cells. Average latency (the age of the mouse, in days, at which the LPD was characterized) and averages of spleen cell numbers (range shown in brackets) are shown below (n = 11 for class A and n = 10 for class B).