Left panel: The notched-wing phenotype of Drosophila melanogaster with thickening of the wing vein, which is a sex-linked recessive trait with a loss of function mutation. Reproduced from Thomas H. Morgan. “The theory of the gene.” The American Naturalist (609):513-544.1917. weblink < http://www.esp.org/books/morgan/theory/facsimile/contents.htm > . Right panel: Flow cytometry showing excess of double negative (TCR αβ + /CD4-/CD8-) T lymphocytes comprising 21% (9985 cells) of the peripheral blood mononuclear cells in a patient with profound lymphoproliferation due to ALPS. (Flow cytometry figure courtesy of Margaret Brown, NIH)

Left panel: The notched-wing phenotype of Drosophila melanogaster with thickening of the wing vein, which is a sex-linked recessive trait with a loss of function mutation. Reproduced from Thomas H. Morgan. “The theory of the gene.” The American Naturalist (609):513-544.1917. weblink < http://www.esp.org/books/morgan/theory/facsimile/contents.htm > . Right panel: Flow cytometry showing excess of double negative (TCR αβ + /CD4-/CD8-) T lymphocytes comprising 21% (9985 cells) of the peripheral blood mononuclear cells in a patient with profound lymphoproliferation due to ALPS. (Flow cytometry figure courtesy of Margaret Brown, NIH)

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