Figure 1
Figure 1. Lack of role of TSLP in IL-7-dependent and independent T lymphopoiesis. (A,B) fluorescence-acivated cell sorting (FACS) profiles and mean (SD) numbers of (A) DN subsets and (B) CD4 and CD8 SP and DP cells in thymus of 9- to 11-week-old littermate WT and Tpte2−/− mice. Data are from 5 littermate WT and 7 Tpte2−/− mice from 3 separate litters. Numbers in FACS profiles show the mean percentages of cells within the indicated gates of total thymocytes. (C-E) Mean (SD) numbers of (C) total thymocytes, (D) DN cells, and (E) CD4 and CD8 SP and DP thymocytes of 3-week-old WT, Il7−/− and Il7r−/− mice. Data are from 4 WT, 7 Il7−/−, and 8 Il7r−/− mice from at least 2 separate litters. (F-H) Mean (SD) numbers of (F) total thymocytes, (G) DN cells, and (H) CD4+ and CD8+ thymocytes of 3-week-old littermate Il7−/− and Il7−/−Tpte2−/− mice. Data are from 7 littermate Il7−/− and 11 Il7−/−Tpte2−/− mice from 4 separate litters. All groups were investigated for statistical differences by Student t test (*P < .05, **P < .01, ***P < .001). Unless otherwise indicated differences were nonsignificant.

Lack of role of TSLP in IL-7-dependent and independent T lymphopoiesis. (A,B) fluorescence-acivated cell sorting (FACS) profiles and mean (SD) numbers of (A) DN subsets and (B) CD4 and CD8 SP and DP cells in thymus of 9- to 11-week-old littermate WT and Tpte2−/− mice. Data are from 5 littermate WT and 7 Tpte2−/− mice from 3 separate litters. Numbers in FACS profiles show the mean percentages of cells within the indicated gates of total thymocytes. (C-E) Mean (SD) numbers of (C) total thymocytes, (D) DN cells, and (E) CD4 and CD8 SP and DP thymocytes of 3-week-old WT, Il7−/− and Il7r−/− mice. Data are from 4 WT, 7 Il7−/−, and 8 Il7r−/− mice from at least 2 separate litters. (F-H) Mean (SD) numbers of (F) total thymocytes, (G) DN cells, and (H) CD4+ and CD8+ thymocytes of 3-week-old littermate Il7−/− and Il7−/−Tpte2−/− mice. Data are from 7 littermate Il7−/− and 11 Il7−/−Tpte2−/− mice from 4 separate litters. All groups were investigated for statistical differences by Student t test (*P < .05, **P < .01, ***P < .001). Unless otherwise indicated differences were nonsignificant.

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