American Society of Hematology

Figure 1

$Figure 1. Effect of IVIG on the leukocyte behavior and RBC capture in TNF-α treated sickle mice. IVIG increases the number of rolling leukocytes. (A) Leukocyte rolling flux represents the number of rolling leukocytes per minute. *P < .05. (B) Leukocyte rolling flux fraction. *P < .05. (C) Number of adherent leukocytes per 100 μm. *P < .05; **P < .01. (D) Scatter plots of the number of leukocytes during the experimental period. Each symbol represents data from a single venule. The increase in leukocyte adhesion over time after TNF-α exposure was abrogated in IVIG-treated compared with PBS-treated control mice. The gray and black dashed regression lines represent PBS-treated and IVIG-treated mice, respectively. (E) Number of interactions between RBCs and adherent WBCs per minute. *P < .05.$

Effect of IVIG on the leukocyte behavior and RBC capture in TNF-α treated sickle mice. IVIG increases the number of rolling leukocytes. (A) Leukocyte rolling flux represents the number of rolling leukocytes per minute. *P < .05. (B) Leukocyte rolling flux fraction. *P < .05. (C) Number of adherent leukocytes per 100 μm. *P < .05; **P < .01. (D) Scatter plots of the number of leukocytes during the experimental period. Each symbol represents data from a single venule. The increase in leukocyte adhesion over time after TNF-α exposure was abrogated in IVIG-treated compared with PBS-treated control mice. The gray and black dashed regression lines represent PBS-treated and IVIG-treated mice, respectively. (E) Number of interactions between RBCs and adherent WBCs per minute. *P < .05.

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