IVIG sustains blood flow rates and prolongs survival in TNF-á–exposed sickle mice. (A) Blood flow rates (nL/sec). *P < .05, **P < .01, and ***P < .001. (B) The Kaplan-Meier survival curves for individual IVIG-treated or control sickle mouse subsets. SS indicates parental sickle mice without transplantation. P = .008, IVIG versus PBS; P = .01, IVIG versus albumin. (C) Survival probabilities when control (PBS and albumin) and IVIG (transplanted and parental) groups are combined. Survival was significantly improved in IVIG-treated mice; log-rank (Mantel-Cox) test; ***P = .0002.