Figure 2
Normal progenitor and stem-cell parameters in Vav-Cre Rb KO animals in BM under steady-state conditions. (A) Total number of cell populations enriched for HPCs (L−S−K+) and HSCs (L−S+K+) in BM of control and Vav-Cre Rb KO animals (n = 5 for control and n = 7 for Vav-Cre Rb KO). (B) Total number of committed progenitor cells (CFCs; n = 7 for control and n = 9 for Vav-Cre Rb KO). (C) Number of cells per CFC colony to determine the proliferative potential of the CFCs (n = 7 for control and n = 9 for Vav-Cre Rb KO). (D) Number of colonies per 1 × 104 cells from primary colonies to determine the self-renewal potential of CFCs (n = 7 for control and n = 9 for Vav-Cre Rb KO). Shown are mean values plus or minus 1 SEM.
