Prognostic relevance for TTT of CD49d in combination with other biologic prognosticators or markers of tumor burden. Kaplan-Meier curves obtained by associating CD49d expression to 3 biologic prognosticators, ie, CD38 (A), ZAP-70 (B), and IGHV gene mutational status (C), or to 3 tumor burden markers, ie, β₂M (D) and sCD23 (E) serum levels and mod-Rai risk groups (F). For each Kaplan-Meier analysis, 4 groups were compared: patients lacking both negative prognosticators, patients with presence of both negative prognosticators, patients with presence of either one unfavorable prognosticator. The numbers of patients (pts) included in each group are reported in parentheses; the reported P values refer to the log-rank test.