Correction of impaired stable platelet adhesion to vWF in Akt–deficient or Akt inhibitor–treated platelets by exogenous cGMP. Washed mouse platelets were preincubated with DMSO or SH-6 (15 μM). WT, Akt1^−/−, or Akt2^−/− platelets were then treated with or without 10 μM 8-bromo-cGMP and immediately allowed to adhere to vWF under constant shear rate (800 s⁻¹) for 5 minutes. After washing, stably adherent platelets were counted under a fluorescence microscope as described in “Platelet adhesion under shear stress.” Data (mean ± SD) were obtained from 10 randomly selected fields from each of 3 experiments. ^###P < .001 versus WT platelets. ***P < .001 versus DMSO–treated WT platelets. *P < .05 versus DMSO-treated WT platelets.