CD18 affects GVHD development. Lethally irradiated BALB/c mice were given intravenous injections of 5 × 10⁶ TCD BM cells from B6 donors alone or with T cells from WT or CD18^−/− B6 donors. (A) Survival of recipients given transplants of TCD BM cells alone (n = 4) or with 1 × 10⁶ WT (n = 8) or CD18^−/− (n = 8) total T cells. (B) Mean changes in percentage of body weights for the recipients as in panel A. (C) Survival of recipients given transplants of TCD BM cells alone (n = 4) or 2 × 10⁶ WT (n = 7) or CD18^−/− (n = 7) T cells after removal of CD25⁺ cells. (D) Mean changes in percentage of body weights for the recipients as in panel B. P values indicate the differences between recipients of WT versus CD18^−/− cells.