The proapoptotic activity of Sema3A is dependent by NP1. (A) Surface expression of NP1 for Jurkat, HUT78, or HUT78.B1 cells. (B) Jurkat cells were incubated with CH11 plus Sema3A-Fc or control IgG for 7 hours, and cell death was determined as described in Figure 1. Alternatively, cells were first incubated with the blocking anti-NP1 antibody or a control Ab. Statistical analysis is shown.