Hypoxia-induced increases in PMN-tissue accumulation in A2BAR bone marrow chimeric mice.A2BAR bone marrow chimeric mice (A: A2BAR^+/+→A2BAR^+/+ and A2BAR^−/−→A2BAR^−/−; B: A2BAR^−/−→A2BAR^+/+ and A2BAR^+/+→A2BAR^−/−) were subjected to either normoxia (room air) or normobaric hypoxia (8% oxygen) for 4 hours, and the heart (Ht), colon (Co), kidney (Kd), lung (Lg), spleen (Sp), brain (Br), muscle (Mu) and liver (Lv) were assessed for PMN accumulation by myeloperoxidase activity (A: *P < .01, compared with normoxia and #P < .01, compared with A2BAR^+/+→A2BAR^+/+ bone marrow chimeric mice and normoxia; B: *P < .01, compared with normoxia and #P < .05, compared with A2BAR^−/−→A2BAR^+/+ bone marrow chimeric mice and normoxia). Error bars represent SD.