SA and its toxins activate STAT3 signaling and increase expression of the IL2R in tumor cells and nonmalignant T cells, thereby stimulating proliferation of tumor cells in CTCL. Antibiotic treatment can effectively eradicate this stimulus, normalize the tumor microenvironment, and inhibit disease activity in skin.

SA and its toxins activate STAT3 signaling and increase expression of the IL2R in tumor cells and nonmalignant T cells, thereby stimulating proliferation of tumor cells in CTCL. Antibiotic treatment can effectively eradicate this stimulus, normalize the tumor microenvironment, and inhibit disease activity in skin.

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