Figure 6.
Effects of α2AP on fibrinolysis. (A) Plasma D-dimer levels in α2AP+/+ and α2AP−/− mice after 5 hours of IVC ligation. The mice were supplemented with 10 mg/kg human fibrinogen. *P < .05 (Student t test). (B) Vein thrombus weight milligram/gram of body weight in α2AP+/+ and α2AP−/− mice after 5 hours’ IVC ligation used for D-dimer measurements ***P < .001 (Student t test). (C) Representative images of IVC thrombus formation in EACA-treated α2AP−/− mice 5 hours after ligation as labeled. (D) Vein thrombus weight (milligram/gram of body weight) in α2AP−/− mice with or without EACA treatment. The horizontal red line in the graph shows the mean vein thrombus weight in α2AP+/+ mice for reference. *P < .05, one-way ANOVA (among 3 groups). (E) Vein thrombus weight (milligram/gram of body weight) in Pg−/− mice in comparison with α2AP+/+ mice. (N = 21) ***P < .001, Mann-Whitney test.

Effects of α2AP on fibrinolysis. (A) Plasma D-dimer levels in α2AP+/+ and α2AP−/− mice after 5 hours of IVC ligation. The mice were supplemented with 10 mg/kg human fibrinogen. *P < .05 (Student t test). (B) Vein thrombus weight milligram/gram of body weight in α2AP+/+ and α2AP−/− mice after 5 hours’ IVC ligation used for D-dimer measurements ***P < .001 (Student t test). (C) Representative images of IVC thrombus formation in EACA-treated α2AP−/− mice 5 hours after ligation as labeled. (D) Vein thrombus weight (milligram/gram of body weight) in α2AP−/− mice with or without EACA treatment. The horizontal red line in the graph shows the mean vein thrombus weight in α2AP+/+ mice for reference. *P < .05, one-way ANOVA (among 3 groups). (E) Vein thrombus weight (milligram/gram of body weight) in Pg−/− mice in comparison with α2AP+/+ mice. (N = 21) ***P < .001, Mann-Whitney test.

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