5hmC in patient-derived cfDNA differs by cell of origin and clinical characteristics. The heat maps are plotted using the final selected genes in each comparison. The 5hmC profiles in cfDNA are shown to be associated with cell of origin (GCB vs ABC, 12 genes) (A), Ann Arbor stages (1/2 vs 3/4, 11 genes) (B), LDH level (elevated vs normal, 18 genes) (C), and the IPI (low = 0/1/2 vs high = 3/4/5, 15 genes) (D).