Figure 2.
Microbiota indirectly regulate hematopoietic progenitors through TLR pathways in hematopoietic cells. Numbers of LSK cells and HSPC subsets in Myd88−/− mice (n = 6 or 7 mice per group) (A) and 3d mice (n = 14-16 mice per group) (B). (C) HSPC analysis from mixed BM chimeras generated with WT and 3d BM cells. Numbers of HSPCs in the BM from chimeric mice (n = 4-7). (D) HSPC analysis from single BM chimeras. Four groups of chimeric mice were generated: WT→WT, WT→3d, 3d→WT, and 3d→3d. Numbers of HSPCs in the BM chimeric mice (n = 5-7). Data are pooled from 2 (C-D) or >2 (A-B) independent experiments with similar results. Data are mean ± standard error of the mean, and each circle represents an individual mouse. *P < .05, **P < .01, ***P < .001, unpaired 2-tailed Student t test (A-C) or 1-way ANOVA with Bonferroni multiple comparison (D).

Microbiota indirectly regulate hematopoietic progenitors through TLR pathways in hematopoietic cells. Numbers of LSK cells and HSPC subsets in Myd88−/− mice (n = 6 or 7 mice per group) (A) and 3d mice (n = 14-16 mice per group) (B). (C) HSPC analysis from mixed BM chimeras generated with WT and 3d BM cells. Numbers of HSPCs in the BM from chimeric mice (n = 4-7). (D) HSPC analysis from single BM chimeras. Four groups of chimeric mice were generated: WT→WT, WT→3d, 3d→WT, and 3d→3d. Numbers of HSPCs in the BM chimeric mice (n = 5-7). Data are pooled from 2 (C-D) or >2 (A-B) independent experiments with similar results. Data are mean ± standard error of the mean, and each circle represents an individual mouse. *P < .05, **P < .01, ***P < .001, unpaired 2-tailed Student t test (A-C) or 1-way ANOVA with Bonferroni multiple comparison (D).

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