WBC indicates white blood cell; RBC, red blood cell; IPSS, International Prognostic Score System; DIPSS, dynamic IPSS; DIPSS+, DIPSS plus; MIPSS, Molecular International Prognostic Score System; and GPS, Genetics-Based Prognostic Scoring System. 1WBC <4 × 109/L or >30 × 109/L in Lille; WBC >25 × 109/L in IPSS, DIPSS, DIPSS+. 2Platelets <100 × 109/L in DIPSS+ and <200 × 109/L in MIPSS. 3DIPSS unfavorable karyotype: complex karyotype or 1 or 2 abnormalities including +8, −7/7q−, i(17q), −5/5q−, 12p−, inv(3) or 11q23 rearrangement; GPSS high-risk: complex without MK, 2 abnormalities not included in very high-risk category, 5q−, +8, other autosomal trisomies except +9, and other sole abnormalities not included in other risk categories; very high-risk: MK, inv(3), i(17q), −7/7q−, 11q or 12p. 4Includes driver mutation status (JAK2/MPL/CALR), as well as ASXL1 and SRSF2.
