Estimated relative incidences of key copy number changes and mutations in childhood BCP-ALL (not mutually exclusive). (A) Relative incidences of 1363 deletions of genes commonly deleted in BCP-ALL calculated from multiplex ligation–dependent probe amplification analysis of 1427 BCP-ALL patients entered into UK childhood ALL treatment trials.22 (B) Estimated distribution of mutations in the common pathways among high-risk childhood BCP-ALL patients.17 Shown are the coding regions and untranslated regions of 125 genes sequenced in 187 high-risk childhood BCP-ALL in the Children's Oncology Group trial COG P9906. Those genes involved in B-cell development and differentiation are color coded in blue and those involved in cell cycle regulation are color coded in red. Mutations affecting the RAS signaling pathway are purple and those affecting the JAKs are green. The transcriptional regulators and others are color coded in black.
