Suggested management of DOAC-associated bleeding. An algorithm for DOAC-associated bleeding is shown. Minor and moderate bleeding may be managed with general hemostatic measures and supportive care. Nonspecific reversal agents, such as PCC or activated PCC may be considered for severe bleeding. CYP3A4 indicates cytochrome P450 3A4; DIC, disseminated intravascular coagulation; and PgP, P-glycoprotein.