Genetic subtypes of Ph-like ALL. (A) Breakdown of Ph-like ALL into CRFL2-rearranged JAK mutant, CRFL2-rearranged JAK wild-type (WT), all other kinase lesions, and unknown. (B) Breakdown of “other kinase lesion” into the indicated subgroups based on genetic alteration. ABL1-class (ABL1, ABL2, CSF1R, PDGFRB); other JAK-STAT (FLT3, IL7R, SH2B3, JAK1/3, TYK2, IL2RB, TSLP); Ras (KRAS, NRAS, NF1, PTPN11, BRAF). HR indicates high-risk. (Adapted with permission from from Roberts et al.²⁰ )