Targetable molecular features of primary mediastinal large B-cell lymphoma and mediastinal gray zone lymphoma. (A) The main activation cascades of JAK-STAT and NF-κB signaling are shown leading to altered transcriptional regulation. Only representative pathway molecules are displayed. Known gene alterations in the pathway are highlighted in color, and pathway inhibitors are shown in the red boxes. (B) A selection of surface markers as part of a PMBCL-specific expression profile is depicted alongside targeted therapeutic approaches. (C) Structural genomic alterations of chromosome 9p24 lead to overexpression of programmed death ligands that are potentially amenable to immunological checkpoint inhibition. Dunleavy and Steidl.⁷