Table 1.
COG classification of newly diagnosed B-precursor ALL (adapted from the COG classification system for B precursor ALL, AALL08B1)86
Favorable genetics: hyperdiploidy with trisomies of chromosomes 4 and 10 or ETV6_RUNX1 fusion. Unfavorable characteristics: CNS2, induction failure, age 13 y and older, hypodiploid (<44 chromosomes or DNA index <0.81), MLL rearrangement, iAMP21. Note that infants and those with Ph+ disease are treated on separate trials.
HR, High risk by age and WBC count; PB, peripheral blood; and SR, standard risk by age and WBC count.
