Prevalence of somatic mutations according to age and risk of development of a hematologic cancer among persons with somatic mutations. (A) Prevalence of somatic mutations according to age among persons not known to have hematologic disorders, estimated based on Xie et al,²⁹  Jaiswal et al,³¹  Genovese et al,³⁰  and McKerrell et al.³²  Gray bands represent 95% confidence interval, calculated with binomial method. (B) Forest plot showing hazard ratios for development of a hematologic cancer among persons with somatic mutations who are not known to have hematologic disorders, according to Jaiswal et al,³¹  and Genovese et al.³⁰  The upper part of the plot reports overall hazard ratio estimated from a meta-analysis of cohorts with the I2 statistic for the heterogeneity between studies, whereas in the lower part hazard ratios are reported according to the presence of candidate driver (CH-CD) or unknown driver (CH-UD) mutation, and to variant allele fraction (VAF of 0.10 or higher). Black diamonds indicate the HR for an individual cohort, while horizontal lines indicate the 95% confidence interval.