Forest plot reporting number of somatic mutations (A) and allele burden (B) in MDS, AA, and clonal hematopoiesis (CH). Black diamonds indicate median values, whereas horizontal lines indicate the 95% confidence interval. For each disease the overall estimate resulted from a meta-analysis of cohorts (blue diamond) is also reported with the I2 statistic for the heterogeneity between studies. Data estimated from Papaemmanuil et al,⁴  Walter et al,⁵  Haferlach et al²⁹  (MDS); Xie et al,²⁹ , Jaiswal et al,³¹  Genovese et al,³⁰  and McKerrell et al³²  (CH); and Kulasekararaj et al³⁶  and Yoshizato et al³⁷  (AA).