Individualized plasma clotting factor activity over time profile: case 1. The red line with hollow points shows the measured plasma clotting factor activities used to estimate the PK profile for the patient (green dashed line). The solid line shows the predicted PK profile for the simulated regimen. The further away the predicted (solid) line is from the measured (hollow point) line and from the estimated (dashed) predicted individual PK profile, the lower our confidence in the precision of the calculation. (A) The threshold after 2000 IU on Monday-Wednesday-Friday. (B) After 2000 units every third day. (C) Every 3.5 days (Sunday morning and Thursday night). The calculations include the weekly average consumption, which is 6000 U with the current regimen, 5000 with solution B, 4000 with solution C. The plots were produced with the calculator function of the WAPPS-Hemo software, a freely available, registration based online tool providing individualized PK profiles using a Bayesian population approach (www.wapps-hemo.org). The interactive graph relative to this example is available at https://demo.wapps-hemo.org/PatientResult.aspx?PIR=Tb1LL6RgexRq8cZ2K5-pEA.