The importance of monitoring patient-reported QoL and symptom burden over time. *For a number of reasons (including side effects), it is possible that QoL might decline at any point along the disease/treatment trajectory. Also, it is likely that the QoL decline might not be as steady as shown in this figure (the trend of the QoL curve reported here is for descriptive purposes only). †One goal of first-line TKI therapy should be to ensure optimal QoL for as long as possible. Any effort should be made to maintain an “acceptable” QoL level for each patient (ie, before reaching the critical threshold below which the risk of poor adherence behavior is heightened).