Gene mutations in PMF. Pie chart illustrates the molecular heterogeneity of primary MF (PMF) based on mutations in JAK2, ASXL1, TET2, SRSF2, DNMT3A, MPL, EZH2, CBL, IDH1, and IDH2. Asterisks depict mutations contributing to epigenetic dysregulation in PMF and/or occurring in epigenetic modifiers. Overlapping mutations (co-occurrence of 2 or more mutations in patients with PMF) are not depicted on this chart so the percentages add up to more than 100%. Chart is created from data derived from mutational analysis of all 10 markers in a cohort of 483 patients with PMF published by Vannucchi et al.⁷