Diversity of the TCRBV and IgH repertoires analyzed by CDR3 spectratyping.

The extent of TCRBV repertoire perturbation is represented as the percent difference between the patient's CDR3 distribution and the corresponding control distribution. A value of perturbation greater than the sum of the SDs relative to each CDR3 length found in normal blood donors is considered abnormal. Panels A to I show TCRBV data in patients nos. 1 to 9, respectively. The bars on the left of the doublets represent CD4 cells and the bars on the right, CD8 cells. ░ indicates, abnormal pattern in CD4 cells; ▪, abnormal pattern in CD8 cells; ■ plus *, normal pattern. Panel J represents IgH data in patients nos. 1 to 9; ░ indicates abnormal patterns; and ■ plus *, a normal pattern.