American Society of Hematology

Fig. 3.

$Fig. 3. Heparin inhibits the flow adhesion of sickle erythrocytes to thrombin-stimulated endothelium in vitro. / (A,B) The number of sickle cells adhering to HUVECs and the rolling velocities of the adhering cells were examined. In 6 experiments the rolling adhesion of sickle cells to thrombin-treated HUVECs was examined in the presence of anti–P-selectin mAb 9E1 or in the presence of unfractionated heparin. Statistically significant differences compared to thrombin-treated HUVECs (†) are indicated. (C) In 3 experiments the firm adhesion of sickle cells to thrombin-treated HUVECs was examined in the presence of anti–P-selectin mAb 9E1 or in the presence of unfractionated heparin. Statistically significant differences (†) are indicated.$

Heparin inhibits the flow adhesion of sickle erythrocytes to thrombin-stimulated endothelium in vitro.

(A,B) The number of sickle cells adhering to HUVECs and the rolling velocities of the adhering cells were examined. In 6 experiments the rolling adhesion of sickle cells to thrombin-treated HUVECs was examined in the presence of anti–P-selectin mAb 9E1 or in the presence of unfractionated heparin. Statistically significant differences compared to thrombin-treated HUVECs (†) are indicated. (C) In 3 experiments the firm adhesion of sickle cells to thrombin-treated HUVECs was examined in the presence of anti–P-selectin mAb 9E1 or in the presence of unfractionated heparin. Statistically significant differences (†) are indicated.

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