Viability and activity of the implanted human liver in myelomatous SCID-hu hosts (SCID B+L).

(A) Representative section stained with hematoxylin and eosin shows the human liver tissue adjacent to the murine kidney at the end of experiment 11 (25 weeks after liver transplantation; original magnification × 200). Similar data were obtained for all hosts implanted with human liver. (B) Human albumin levels in the serum of SCID-hu B+L (n = 16) are significantly higher than in SCID-hu B (n = 18) mice (P < .0001). Error bars represent SEMs. Thalidomide had no effect on levels of human albumin in thalidomide-treated hosts (see “Results”).